JNS.jpgThe May issue of the Journal of the Neurological Sciences Vol 376 is now available online.


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Issue highlights

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Muscle strength and power in persons with multiple sclerosis – A systematic review and meta-analysis

To systematically review 1) the psychometric properties of isokinetic dynamometry testing in PwMS, and 2) studies comparing muscle mechanical function in PwMS to matched healthy controls (HC). In addition, a meta-analysis will evaluate 3) the effects of progressive resistance training on muscle mechanical function in PwMS.


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Role of inflammatory molecules in the Alzheimer's disease progression and diagnosis

Several genetic, environmental, and physiological factors, including inflammations and metabolic influences, are involved in the progression of AD. Inflammations are composed of complicated networks of many chemokines and cytokines with diverse cells. Recent studies demonstrated that inflammation may be involved in neurodegenerative dementia. Cellular immune components, such as microglia or astrocytes, mediate the release of inflammatory molecules, including tumor necrosis factor, growth factors, adhesion molecules, or chemokines. This review summarizes the role or possible role of immune cells and inflammatory molecules in disease progression or prevention.


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Two decades of glatiramer acetate: From initial discovery to the current development of generics

Open Access

In the United States, several US Food and Drug Administration (FDA)-approved disease-modifying treatments (DMTs) are available, including glatiramer acetate (GA; Copaxone®), one of the most longstanding treatments. GA was discovered serendipitously in the late 1960s/early 1970s while attempting to produce a synthetic antigen capable of inducing experimental autoimmune encephalomyelitis (EAE), an animal model of autoimmune inflammatory CNS disorders, including MS. Instead, GA was found to be protective in EAE models.


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T2 relaxometry helps prognosticate seizure outcome in patients with solitary cerebral cysticercosis

Correlate serial T2 relaxometry (T2R) values with long term seizure outcome in patients with solitary cerebral cysticercosis (SCC) in order to establish its usefulness as a prognostic marker in these patients.