JNS.jpgThe June issue of the Journal of the Neurological Sciences Vol 377 is now available online.


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Issue highlights

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Lewis P. Rowland: August 3, 1925–March 16, 2017

Lewis P. Rowland, universally known, as 'Bud' died at age 91 on March 16, 2017. With his passing, the world lost one of the great figures in neurology. A graduate of Erasmus Hall High School in Brooklyn, NY, Bud received his bachelor's degree in 1945 and his MD in 1948, both from Yale University. He completed his internal medicine residency at Yale and then a neurology residency at the Neurological Institute of New York/Columbia University College of Physicians and Surgeons. Bud was at NINDS for a short time during the McCarthy era but was dismissed after he refused to be interviewed by the FBI about the American Association of Interns and Residents.


Editor's update and selected articles from the journal of the neurological sciences

One of the prime missions of the Journal of the Neurological Sciences is to highlight activities of the World Federation of Neurology (WFN). Along those lines, I wish to remind everyone that the XXIII World Congress of Neurology (WCN) will be held on 16–21 September 2017 in Kyoto, Japan. The Congress will be co-hosted by the Japanese Society of Neurology and the Asian and Oceanic Association of Neurology. The theme of WCN 2017 is "Defining the Future of Neurology". The XXIII WCN will have a series of programs and lectures led by leading scientists, clinicians, public health experts and policy-makers from around the world.


Rituximab in anti-MAG neuropathy: More evidence for efficacy and more predictive factors

Almost 50% of patients with benign IgM monoclonal gammopathy of undetermined significance (MGUS) may have or develop, a slowly progressive large-fiber polyneuropathy predominantly manifested as sensory ataxia but often combined with a varying degree of distal and proximal muscle weakness [1,2]. Electrophysiology demonstrates slow conduction velocity with characteristic prolonged distal motor and sensory latencies indicative of distal demyelination [3]. The IgM in more than 50% of the patients reacts with the carbohydrate component of myelin-associated glycoprotein (MAG), a 100-kDa glycoprotein of the central and peripheral nerve myelin [4], and with an acidic glycolipid in the ganglioside fraction of the human peripheral nerve, identified as a sulfoglucuronyl glycosphingolipid (SGPG) [5]; 75% of the rest recognize other ganglioside antigens [5].


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Juvenile dermatomyositis/polymyositis and lymphoma

In patients with juvenile dermatomyositis/polymyositis (JDM/PM), malignancy is a rare phenomenon. An extensive workup for neoplastic disease is not routinely indicated, but should be considered if unusual physical findings are noted at JDM/PM diagnosis or during follow-up period. The objective of this literature review was to assess for any association between, and disease profile of, JDM/PM and lymphoma in childhood. Risk determinants of the possible development of lymphoma in the pediatric population with JDM/PM appear to be the degree and duration of inflammatory activity with chronic B-cell activation and/or antigen stimulation; a paraneoplastic relationship is unlikely.