JNS.jpgThe September issue of the Journal of the Neurological Sciences Vol 380 is now available online.


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Issue highlights

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Arterial stiffness and cognitive impairment

  • Arterial stiffness is positively related to cognitive impairment and could be used to predict cognitive decline.
  • Mechanisms mediating the relationship between arterial stiffness and cognitive impairment may be related to cerebral small vessel diseases.
  • Early intervention of vascular stiffness such as physical exercise, nitrite and tea may help prevent cognitive impairment.


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Retroviral envelope proteins: Involvement in neuropathogenesis

  • The pathogenic potential of retroviral Env is not limited to infection per se.
  • Pathogenic potential of Env may be fusion, cell death, induction of cytokines.
  • The retroviral Env itself has pathogenic/toxic capacity.
  • HERV encoded Envs may be useful therapeutic targets in some neurological diseases.


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Tele-neurology in sub-Saharan Africa: A systematic review of the literature

The rapid advancement in telecommunications on the African continent has opened up avenues for improving medical care to underserved populations. Although the greatest burden of neurological disorders is borne by Low-and-Middle Income Countries (LMICs) including sub-Saharan Africa (SSA), there is a profound paucity of neurologists to serve the population. Telemedicine presents a promising avenue for effective mobilization and utilization of the few neurologists in Africa.


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Management of glioblastoma in elderly patients

  • A substantial proportion of patients with glioblastoma are elderly, in turn, understanding their optimal management is important for physicians treating these patients.
  • Radiation alone is associated with longer survival compared to supportive care alone. A shorter course of radiation is often preferable in the elderly population.
  • Chemotherapy alone can be considered in this patient population.
  • A combination of short-course radiation and temozolomide chemotherapy is associated with longer overall survival and progression free survival compared to short-course radiation alone.
  • It will be important to understand the underlying biology of the disease in elderly patients as we investigate future treatment strategies including immunotherapeutic approaches.