JNS.jpgThe November issue of the Journal of the Neurological Sciences Vol 381 is now available online.

 

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Issue highlights

Timely therapy requires timely diagnosis; high risk therapy demands accurate diagnosis

Temporal lobe epilepsy (TLE) is the most common form of refractory focal epilepsy. This review investigated the state of research regarding neuropsychological impairment and neuroimaging studies in TLE patients. Results showed significant alterations in multiple cognitive domains, particularly memory, executive functions and language. The reported findings showed that the involvement of various factors, including neurobiological abnormalities and clinical features, is responsible for the onset of cognitive impairment in epileptic patients.

 


Carotid artery stenosis and PERI-operative stroke in cardiac surgery. A bridge between heart and brain

The cerebral injury following cardiac surgery encompasses a wide spectrum of clinical disorders ranging from acute cerebrovascular events to cognitive dysfunction. Despite improvement in surgical expertise and anesthetic techniques and advancement in brain protection strategies, it still represents a striking clinical issue whose incidence has not been significantly lowered over the time. In this regard, there is accruing evidence that patient-related variables may play a role, and the risk stratification should be of aid to tailor treatment strategies, reduce the hazard of post-procedural complications and improve the outcome.

 


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Spinal nerve involvement in early Guillain-Barré syndrome: The Haymaker and Kernohan's legacy

Pathological studies of early Guillain-Barré syndrome (GBS), defined as of 10 days of disease onset, are scanty making it difficult to interpret the physiopathology of clinical and electrophysiological features. 

  • The brunt of pathology in early Guillain-Barré syndrome (GBS) relies on spinal nerves (Haymaker and Kernohan [1] ).
  • The initial lesion is endoneurial oedema.
  • Spinal nerve involvement is a hotspot in early GBS, either demyelinating or axonal.
  • This notion is essential to understand its physiopathology.

 


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Advancing stroke genomic research in the age of Trans-Omics big data science: Emerging priorities and opportunities

Understanding the genomic determinants of stroke and the corresponding molecular mechanisms will revolutionize the development of a new set of precise biomarkers for stroke prediction, diagnosis and prognostic estimates as well as personalized interventions for reducing the global burden of stroke.

  • Global burden of stroke can be reduced through elucidation of genomic determinants.
  • Current few validated genetic variants cannot account for the full risk of stroke.
  • None of the reviewed genetic studies included continental Africans.
  • Genomic study of stroke among Africans presents a unique opportunity for discovery.
  • Findings from such studies may have implications for global populations.