In an analysis of data for 195 countries, the Global Burden of Disorders Study Group found that neurological disorders caused 250.7 million disability-adjusted life years (DALYs) in 2015, an increase of 7.4 percent from 1990. Stroke was reported to be one of the leading causes of DALYs worldwide.

Neurological diseases are the world's largest cause of disability-adjusted life years (DALYs), or years of healthy life lost to due to death or disability, according to a systematic analysis performed for the Global Burden of Disease Study 2015, the most current overview of the way neurological diseases are affecting people around the world.

Neurologists specializing in global health told Neurology Today the analysis brings into sharp focus the immense burden of neurological disorders around the globe. Importantly, they said, its bold statement should help free up resources for neurological care, while the country-by-country breakdown — data for 195 nations are included — will help guide the way forward in addressing the problems faced around the world.

Published in the September 17 online edition of Lancet Neurology, the analysis includes data for disease groupings broken down from a myriad of perspectives: nation, socio-demographics, age, gender, and in proportion to one another.

The analysis is largely a story about the devastating impact of stroke — no longer categorized as a cardiovascular disorder but as neurological by the World Health Organization (WHO) and the Global Burden of Disease study group.

With stroke included for the first time in such a broad and detailed analysis, neurological disorders caused 250.7 million DALYs in 2015, an increase of 7.4 percent from 1990.

The most surprising findings were the amount of increase in the burden from 1990 to 2015 in virtually all countries of the world and that neurological disorders are now the leading causes of disability among all groups of diseases.
Valery Feigin, MD, PhD, a lead author of the analysis and director of the National Institute for Stroke and Applied Neurosciences at Auckland University of Technology in New Zealand.

Jerome H. Chin, MD, PhD, MPH, FAAN, chair of the International Subcommittee of the AAN and adjunct professor of neurology at New York University, said the report illustrates how the burden of neurological disorders is “substantial, varied, and growing.”

Despite improvements in the prevention and treatment of some neurological disorders, for example, stroke, meningitis, and epilepsy, the absolute global burden has increased as a result of population expansion and increasing life expectancies. Currently, 84 percent of the world's population resides in low- and middle-income countries where most of the population growth is occurring. The fastest growing region is sub-Saharan Africa whose population will double in the next few decades. Stroke is clearly the biggest threat to neurological health globally, responsible for 47 percent of the global burden of neurological disorders.
Jerome H. Chin, MD, PhD, MPH, FAAN, chair of the International Subcommittee of the AAN and adjunct professor of neurology at New York University

Wolfgang Grisold, MD, Secretary General of the World Federation of Neurology (WFN), said that with this study, the authors were “courageous enough to reach over the prevalent corset of classification,” thereby “allowing a more expanded and timely view on the prevalence of neurological diseases.”

The new study provides important evidence that brain diseases have moved on from an under-estimated, under-recognized, and under-resourced group of conditions to a major challenge for health policy worldwide and that sufficient resources have to be provided for disease prevention and management. The WFN cooperates with a wide range of organizations at the global and regional level to address this challenge. The important impact of neurological diseases on global health is increasingly being discussed in the framework of international organizations.
Wolfgang Grisold, MD, Secretary General of the World Federation of Neurology (WFN)

The WHO Global NCD (non-communicable diseases) Action Plan 2013-2020 and the Sustainable Development Goals of the United Nations are two projects aimed at the prevention of neurological conditions.

But he added that the recent WHO-WFN Neurology Atlas publication “shows that the resources available for neurological diagnosis, therapy, and access to neurological care are still very unevenly distributed globally. These new data will give us additional arguments to make the point that sufficient resources for brain health have to be provided at all levels.”

WFN is also devoted to improving neurological care worldwide, he said, with a program to “ensure knowledge transfer across national borders,” with low-income countries as the main target.

The disparity and inequalities of health systems, the lack of financial resources in many countries, cultural and religious hurdles, as well as political aspects are among the major obstacles to making more progress in the field of neurological care on the global scale. The World Stroke Organization (WSO) is leading awareness campaigns among the general population and among health professionals. We advise decision-makers and governmental bodies on best scientifically-based policies. We arrange stroke congresses, and we have many education activities ongoing. The greatest barriers relate to shortage of resources in the health system, the underfunding of stroke services, and the difficulties to change established habits.
Bo Noorving, MD, PhD, past president of the WSO.

He said that the organisation will continue its strong advocacy for stroke resources and that stroke “is no longer invisible under the umbrella of ‘cardiovascular diseases,’ but identified on its own as one of the core NCDs, possible to prevent and treat.”


View Full Article