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Issue highlights

Experimental sheep BSE prions generate the vCJD phenotype when serially passaged in transgenic mice expressing human prion protein

Open Access

  • Investigation of sheep BSE prions in transgenic mice expressing human prion protein.

  • Observed molecular and neuropathological phenotypes are congruent with vCJD.

  • Sheep BSE prions could have acted as a causal agent of vCJD within Europe.

The epizootic prion disease of cattle, bovine spongiform encephalopathy (BSE), causes variant Creutzfeldt-Jakob disease (vCJD) in humans following dietary exposure.

While it is assumed that all cases of vCJD attributed to a dietary aetiology are related to cattle BSE, sheep and goats are susceptible to experimental oral challenge with cattle BSE prions and farmed animals in the UK were undoubtedly exposed to BSE-contaminated meat and bone meal during the late 1980s and early 1990s.

Here we report that serial passage of experimental sheep BSE prions in transgenic mice expressing human prion protein with methionine at residue 129, produces the vCJD phenotype that mirrors that seen when the same mice are challenged with vCJD prions from patient brain.

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The association of adult vaccination with the risk of cerebrovascular ischemia: A systematic review and meta-analysis

There is mounting evidence supporting infection as an independent risk factor for ischemic stroke (IS), while preliminary data indicate that vaccination may prevent IS.

This study performed a systematic review and meta-analysis of available randomized clinical trials (RCTs) or prospective observational cohorts reporting associations of influenza vaccination (IV) and/or pneumococcal vaccination (PV) with IS.

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Cognition in multiple sclerosis: Between cognitive reserve and brain volume

Several correlations between cognitive impairment (CI), radiologic markers and cognitive reserve (CR) have been documented in MS. This study evaluates the correlation between CI and brain volume (BV) considering CR as a possibile mitigating factor.

By carrying out a neuropsychological assessment MS patients, the study demonstrated a correlation between cognition and BV, in particular grey matter volume. Cognitive reserve is also confirmed as an important element playing a role in the complex interaction to determine the cognitive functions in MS.

Feasibility study of a targeted self-management intervention for reducing stroke risk factors in a high-risk population in Uganda

Stroke remains a global concern due to increasing lifespan, patterns of industrialization, adoption of harmful western diets, and an increasing prevalence of risk factors such as hypertension, obesity, and diabetes.

The study investigated an adopted novel self-management intervention, TargetEd mAnageMent Intervention (TEAM) to reduce modifiable stroke risk factors in Uganda.

Through a six-month, uncontrolled, prospective pilot study to establish feasibility, acceptability and preliminary efficacy of TEAM in Ugandans at high risk for stroke, the team concludes that targeted training in self-management adapted to the Ugandan setting is feasible, highly acceptable to participants and appears to be associated with reduced blood pressure, improved lipid profiles and improved glucose control in diabetics.

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