Considering the growing evidence that we can prevent some dementias by preventing stroke beginning now, the World Stroke Organisation has launched a Proclamation calling for a joint prevention of stroke and potentially preventable dementias.

Download Stroke and Potentially Preventable Dementias Proclamation

Stroke and dementia are among the leading causes of disability and impairment of quality of life in old age. Vascular diseases are the second most common cause of dementia after Alzheimer's disease, and often contribute to the development of primary neurodegenerative dementias. While therapeutic breakthroughs in the neurodegenerative causes of dementia are still pending, improvements in vascular prevention and stroke treatment offer new and effective approaches to the prevention of dementia.

Concomitant with the implementation of a successful stroke strategy, the incidence of stroke declined by 32% and that of dementia of 7% over a 12 year period1. Since stroke doubles the chances of developing dementia and is in principle, 90% preventable2 we can begin preventing stroke and some dementias now. Multiple life interventions improve cognition, even APoE4 positive individuals3 and treating atrial fibrillation with anticoagulants can reduce the risk of dementia by 48%4.

A meeting addressing this evidence in depth and outlining the actionable conclusions will take place in Berlin, Germany on Saturday, October 13, 2018 as a satellite. At the World Health Summit will be a session presenting the main conclusions:

  • Diverging trends in stroke and dementia: Prevention opportunities Suvarna Alladi, India
  • Stroke as a form and a trigger of neurodegeneration Zaven Khachaturian, USA
  • The brain risk reduction initiative of the World Dementia Council Yves Joanette, Canada
  • Preventing dementia by preventing stroke: The bases for action Vladimir Hachinski, Canada

 

  1. Sposato LA, Kapral MK, Wu J, Gill SS, Hackam DG, Cipriano LE, Hachinski V. Declining incidence of stroke and dementia: Coincidence or prevention opportunity? JAMA Neurol. 2015:72;1529-1531
  2. O'Donnell MJ, Xavier D, Liu L et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): A case-control study. Lancet 2010;376:112-123
  3. Solomon A, Turunen H, Ngandu T, Peltonen M, Levalahti E, Helisalmi S, Antikainen R, Backman L, Hanninen T, Jula A, Kivipelto M. More Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial. JAMA Neurol 2018;75:462-470
  4. Friberg L, Rosenqvist M. Less dementia with oral anticoagulation in atrial fibrillation. Eur Heart J. 2018 Feb 7;39(6):453-460

A satellite symposium at the World Health Summit, October 13, 2018 Berlin, Germany on Dementia Prevention by Stroke Prevention.

Open for all

October 13, 2018
Location: Kosmos, Karl-Marx-Allee 131a, 10243 Berlin, Germany
Hosts: Center for Stroke Research Berlin, Kompetenznetz Schlaganfall, Institute for Stroke and Dementia Research, Deutsches Zentrum für Neurodegenerative Erkrankungen, NeuroCure, SyNergy

Speakers will include renowned experts from Canada, Germany, India, Sweden, United Kingdom, and the USA.

Program

10:00 - Setting the Scene

Chairs:
Vladimir Hachinski – London, Ontario, Canada
Karl Max Einhäupl - Charité-Universitätsmedizin Berlin, Germany

  • Dementia prevention by stroke prevention: call for action
    Vladimir Hachinski – London, Ontario, Canada
  • Dementia in aging societies and opportunities for prevention
    Carol Brayne – Cambridge Institute of Public Health, UK
  • Diverging trends in dementia
    Suvarna Alladi – National Institute of Mental Health and Neurosciences, Bengaluru, India

11:20 - Coffee Break

11:40 - Now is the time

Chairs:
Martin Dichgans – Ludwig-Maximilians Universität München, Germany
Matthias Endres – Charité-Universitätsmedizin Berlin, Germany

  • Less dementia with oral anticoagulation in atrial fibrillation
    Leif Friberg – Karolinska Institute, Stockholm, Sweden
  • Post-Stroke Dementia: mechanisms and opportunities for prevention
    Martin Dichgans – Ludwig-Maximilians Universität München, Germany
  • Vascular dysregulation: A Key Triggering Factor of Late Onset Alzheimer's Disease
    Yasser Iturria Medina – Montreal Neurological Institute and Hospital, Canada

13:00 - Lunch

14:00 - Targets for Dementia Prevention: Vessels and Molecules

Chairs:
Ulrich Dirnagl – Charité-Universitätsmedizin Berlin, Germany
Arno Villringer – Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

  • Cerebral amyloid angiopathy as a target for dementia prevention
    Steven Greenberg – Harvard Medical School, Boston, USA
  • The vascular biology of dementia
    Costantino Iadecola – Cornell University, New York, USA
  • Cerebral small vessel disease: novel targets for prevention
    Joanna Wardlaw – UK Dementia Research Institute, University of Edinburgh, UK

15:20 - Coffee Break

15:40 - Roadmap for Dementia Prevention

Chair:
Zaven Khachaturian – Editor-in-chief, Alzheimer & Dementia

  • Facilitating research for dementia prevention: the German Center for Neurodegenerative Diseases
    Pierluigi Nicotera – German Center for Neurodegenerative Diseases, Bonn, Germany
  • Action Plan for Stroke in Europe
    Bo Norrving – Lund University, Sweden
  • Turning knowledge into action: lessons from stroke
    Werner Hacke – University of Heidelberg, Germany
  • Next steps and concluding remark
    Zaven Khachaturian – Editor-in-chief, Alzheimer & Dementia

 

Center for Stroke Research Berlin      Kompetenznetz Schlaganfal (CompetenceNet Stroke)Institute for Stroke and Dementia Research  DZNE - German Center for Neurodegenerative Diseases  NeuroCure - Cluster of Excellence  SyNergy – "Munich Cluster for Systems Neurology"