JNS.jpgThe September issue of the Journal of the Neurological Sciences Vol 392 is now available online.


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Issue highlights

Meningioangiomatosis: A review of the variable manifestations and complex pathophysiology

Meningioangiomatosis (MA) is a rare, complex and heterogeneous disease of meningovascular proliferation that is found primarily in the leptomeninges and cerebral cortex but can involve subcortical white matter and other brain regions such as the cerebellum and deep gray matter.

In this article, we review the various manifestations of MA including neurofibromatosis-associated MA, multifocal MA, cystic MA, and MA associated with meningioma, other brain tumors, focal cortical dysplasia, neurodegenerative changes, and post-radiation changes. The treatment of MA is also reviewed.

While the pathogenesis of MA remains elusive, we discuss the proposed theories such as developmental, dysplastic, hamartomatous or reactive ethology in given variants. It is important for physicians to be aware of MA as more research on this complex entity is needed and timely diagnosis may benefit outcomes in patients with MA.

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Peripheral neuropathic pain in idiopathic Parkinson's disease: Prevalence and impact on quality of life; a case-controlled study

Pain is a frequent and debilitating non-motor symptom of Idiopathic Parkinson's Disease (IPD). The present study investigated the prevalence of pain and specifically peripheral neuropathic pain (PNP) in IPD, and ascertained any impact of PNP on quality of life (QoL).

The influence of levodopa, entacapone and homocysteine on prevalence of polyneuropathy in patients with Parkinson's disease

Parkinson's disease (PD) is a chronic progressive disease of the nervous system. Recently, there has been a growing amount of evidence about peripheral nervous system being affected in PD patients.

This study's findings support the hypothesis that long-term levodopa treatment and elevation of serum homocysteine are risk factors for polyneuropathy, and that Entacapone has protective influence on polyneuropathy development in PD patients.

Superficial siderosis associated with duplicated dura mater detected by CISS reverse MRI

Superficial siderosis (SS) of the central nervous system is a rare disease caused by chronic or repeated hemorrhages in the subarachnoid space. Closure of dural defects is an effective therapy for SS. Conventional magnetic resonance imaging (MRI), however, cannot sufficiently detect dural tears. To better detect these defects, we analyzed the clinical data of consecutive patients admitted to our department with SS and performed constructive interference in steady-state (CISS) reverse MRI of the brain and spinal cord. CISS reverse method emphasizes the contrast between the dura and cerebrospinal fluid, enabling detection of dural defects better than usual T2-weighted MRI.

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