JNS.jpgThe January issue of the Journal of the Neurological Sciences Vol 396 is now available online.

 

Click here to access

 

Issue highlights

Outcome of human peripheral nerve repair interventions using conduits: a systematic review

  • High quality randomized controlled trials on peripheral nerve injury outcome are scanty
  • Most existing studies with well-characterised intervention and outcome measures are inadequately powered
  • A meta-analysis of three RCTs meeting above criteria with adequate homogeneity were identified
  • Human peripheral nerve repair using conduits for sensory nerves significantly more effective than direct nerve suture
  • Sufficiently powered high-quality RCTs are needed to determine efficacy of conduits on motor and mixed nerve repairs
Abstract Image

Huntington disease: A quarter century of progress since the gene discovery

  • Discovery of the genetic cause for Huntington disease (HD) opened the "gene hunter" era.
  • Discoveries are still being made on phenotype-CAG length relationships, why CAG lengths expand, and age of onset modifiers.
  • Research on non-choreic and non-motor features drives current debate over how to best diagnose clinical and preclinical HD.
  • Symptomatic care focused on function and quality of life can make a significant positive impact at all stages of HD.
  • Novel disease-modifying therapeutics leverage several mechanisms, most prominently huntingtin lowering strategies.

Natalizumab exposure during pregnancy in multiple sclerosis: a systematic review

  • Spontaneous abortion rate in natalizumab exposure subjects varied from 9.4% to 17.4%.
  • Major birth defects rate varied from 2.9% to 5.1% in natalizumab exposure subjects.
  • After natalizumab discontinuation during pregnancy, the relapse rate varied from 21.4% to 36.5%.

Hydrogen as a complementary therapy against ischemic stroke: A review of the evidence

  • We summarized the therapeutic effect and mechanism of hydrogen to ischemic stroke or cerebral I/R injury.
  • Anti-oxidation, anti-inflammation and anti-apoptosis are essential mechanisms of hydrogen.
  • We come up with several new outlooks about the investigation of hydrogen therapy.
  • Hydrogen therapy is an ideal complementary therapy to ischemic stroke.
Abstract Image