JNS.jpgThe February issue of the Journal of the Neurological Sciences Vol 397 is now available online.


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Issue highlights

HIV related motor neuron disease/syndrome: The - potentially treatable - retroviral link in ALS?

A viral etiology of ALS or at least contribution to its pathophysiology as an environmental risk factor is a plausible proposition, considering the exquisite neurotropism and neurovirulence of some viruses towards motor neurons.

Editorial for adult CSF total protein: Higher upper reference limits should be considered worldwide. A web-based survey

The cerebrospinal fluid total protein level is commonly used as an indicator or marker of several diseases of the peripheral - (PNS) and central nervous system (CNS). Worldwide most laboratories use the upper reference limit of 0.45 g/L for CSF protein. Based on own investigations and a global survey the authors of this paper research the worldwide upper reference limits. The overarching question was, if this upper limit was a fixed level, or subject to age-related changes.

This investigation refers to CSF usually obtained by lumbar puncture and does not consider the ventricular CSF, nor children.

Immediate versus delayed detection of Takotsubo syndrome after epileptic seizures

Takotsubo syndrome (TTS) is characterized by transient systolic left ventricular dysfunction, most frequently in the apical region, which cannot be explained by coronary artery disease. The clinical presentation, electrocardiographic (ECG) findings, and biomarker profiles are often similar to those of an acute coronary syndrome.

The aim of the present review was to screen the literature for information about the interval between epileptic seizure and TTS.

  • Seizure-induced Takotsubo syndrome may be detected immediately or delayed.
  • Takotsubo syndrome can be overlooked due to lack of typical symptoms.
  • Postictally, a 12-lead electrocardiogram should be recorded and troponin levels should be measured. In cases with troponin elevation, surveillance is recommended.
  • New T-wave inversions in the electrocardiogram might indicate seizure-induced Takotsubo syndrome
  • >Due to lack of data the optimal duration for surveillance is unclear.
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Urban-rural differences in the care and outcomes of acute stroke patients: Systematic review

To describe literature pertaining to urban-rural differences in both the quality of care and outcomes of acute stroke patients.

  • Access to acute stroke care differs between urban and rural areas, particularly where thrombolysis is concerned.
  • No significant differences were found between the outcomes of urban and rural patients.
  • Researchers are not utilising the best available methods to examine regional differences in stroke patient outcomes.
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